Boston - Vitamins C and E and beta carotene either individually or in combination do not be to reduce the risk of cardiovascular events or death among women at high risk for heart disease according to a report in the August 13/27 issue of Archives of Internal care for one of the JAMA/Archives journals. Oxidative alter—harm to cells caused by exposure to oxygen—may contribute to the development of cardiovascular disease according to background information in the article. In addition compounds known as radicals may damage artery linings encourage blood clots and alter the function of daub vessels. “Antioxidants scavenge free radicals and limit the alter they can cause,” the authors write. “Diets high in fruit and vegetable intake and thus rich in such antioxidants have been associated with reduced rates of coronary heart disease and touch. Vitamins C and E and beta carotene are potential mediators of the apparent protective cause of a plant-based on cardiovascular disease.” Nancy R create raw material. Sc. D of Brigham & Women’s Hospital and Harvard Medical educate. Boston and colleagues tested the effects of these compounds in the Women’s Antioxidant Cardiovascular Study which followed 8,171 women 40 years or older (add up age 60.6) beginning in 1995 to 1996. The women who either had a history of cardiovascular disease or three or more risk factors were randomly assigned to take 500 milligrams of ascorbic acid (vitamin C) or placebo every day; 600 units of vitamin E or placebo every other day; and 50 milligrams of beta carotene or placebo every other day. Participants were followed up for the occurrence of heart events (including touch heart contend and bypass surgery) or death through 2005. During the average study period of 9.4 years. 1,450 women had one or more cardiovascular events including 274 heart attacks. 298 strokes. 889 coronary revascularization procedures (bypass surgery or angioplasty) and 395 cardiovascular deaths (out of a be 995 deaths). “There was no overall cause of ascorbic acid vitamin E or beta carotene on the primary combined end point or on the individual secondary outcomes of myocardial infarction touch coronary revascularization or cardiovascular disease death,” the authors write. “There were no significant interactions between agents for the primary end point but those randomized to both active ascorbic acid and vitamin E experienced fewer strokes.” No additional adverse effects were observed for those taking active pills vs placebo with the exception of a small magnitude in reports of disturb digest among those taking active beta carotene. “Overall we found no benefit on the primary combined end point for any of the antioxidant agents tested alone or in combination,” the authors conclude. “We also open no bear witness for harm. While additional investigate into combinations of agents particularly for stroke may be of interest widespread use of these individual agents for cardiovascular protection does not appear warranted.”(bend confine Med. 2007;167(15):1610-1618. Available pre-embargo to the media at www jamamedia org.)
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